Tata Laksana Keracunan Ethylene Glycol dan Diethylene Glycol

Authors

  • Johan Indra Lukito Dokter Umum, Jakarta, Indonesia

DOI:

https://doi.org/10.55175/cdk.v50i2.526

Keywords:

Diethylene glycol, ethanol, ethylene glycol, fomepizole, keracunan

Abstract

Ethylene glycol (EG) dan diethylene glycol (DEG) adalah senyawa alkohol toksik berbentuk cairan dengan rasa manis; senyawa ini dapat ditemukan di beberapa alat rumah tangga, zat antibeku, dan pelarut automotif dan industri. Keracunan akibat konsumsi bisa fatal. Keracunan EG dan DEG merupakan keadaan darurat medis yang membutuhkan diagnosis segera dan pengobatan agresif meliputi terapi suportif, antidot fomepizole atau ethanol, dan hemodialisis.

Ethylene glycol (EG) and diethylene glycol (DEG) are toxic alcohol compounds in the form of liquids with a sweet taste found in some household appliances, antifreeze agents, and solvents for automotive and industrial purposes. Poisoning from ingestion can be fatal. EG and DEG poisoning are medical emergencies requiring prompt diagnosis and aggressive treatment, including supportive therapy, antidotes fomepizole or ethanol, and hemodialysis.

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References

Iqbal A, Glagola JJ, Nappe TM. Ethylene glycol toxicity [Internet]. 2022 [cited 2022 October 21]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537009/

Medscape. Ethylene glycol toxicity [Internet]. 2021 [cited 2022 October 21]. Available from: https://emedicine.medscape.com/article/814701-overview

Schep LJ, Slaughter RJ, Temple WA, Beasley DM. Diethylene glycol poisoning. Clin Toxicol (Phila). 2009;47(6):525-35.

Bornhorst JA, Mbughuni MM. Chapter 3 - Alcohol biomarkers: Clinical issues and analytical methods in critical issues in alcohol and drugs of abuse testing (Second Edition). 2019:25-42

Agency for Toxic Substances and Disease Registry. What are the toxicological effects of ethylene glycol poisoning? [Internet]. 2021 [cited 2022 October 21]. Available from: https://www.atsdr.cdc.gov/csem/ethylene-propylene-glycol/toxicological_effects.html#:~:text=Ethylene%20glycol’s%20toxicity%20mainly%20results,the%20first%20hours%20after%20exposure.

Scalley RD, Ferguson DR, Piccaro JC, Smart ML, Archie TE. Treatment of ethylene glycol poisoning. Am Fam Physician. 2002;66(5):807-12.

Medscape. Fomepizole [Internet]. 2022 [cited 2022 October 21]. Available from: https://reference.medscape.com/drug/antizol-fomepizole-343713#0

Mégarbane B. Treatment of patients with ethylene glycol or methanol poisoning: Focus on fomepizole. Open Access Emerg Med. 2010;2:67-75.

Medscape. Ethanol [Internet]. 2022 [cited 2022 October 21]. Available from: https://reference.medscape.com/drug/alcohol-ethyl-ethanol-343730

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Published

01-02-2023

How to Cite

Lukito, J. I. (2023). Tata Laksana Keracunan Ethylene Glycol dan Diethylene Glycol. Cermin Dunia Kedokteran, 50(2), 92–96. https://doi.org/10.55175/cdk.v50i2.526